Stable isotope-labeled internal standards have been proven to overcome these problems and compensate for fluctuations in sample preparation, such as extraction and cleanup. Numerous LC/MS/MS methods for detecting mycotoxins have been developed and published in recent years; however, only a few so far have been based on stable isotope-labeled analytes, mainly due to their limited availability and quality. Only recently have calibrants of thoroughly [13C]-labeled mycotoxins been introduced, thus opening a broad field of applications and improvement in mycotoxin analysis. The challenge for the industry is to accelerate the development of unified multi-toxin methods suitable for many types of analyte/matrix combinations.
Dr. Eva-Maria Binder is chief scientific officer at the Erber Group. She can be reached at firstname.lastname@example.org.
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